Thermal effects in the organocatalytic asymmetric Mannich reaction.
نویسندگان
چکیده
The proline-catalyzed direct asymmetric Mannich reaction between cyclohexanone, formaldehyde, and various anilines is thermally accelerated. With only 0.5 mol % of catalyst, Mannich products with up to 98% ee have been obtained after a short period of time in reactions performed under microwave irradiation. In situ reduction of the resulting ketones affords N-aryl amino alcohols in up to 86% yield.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 71 7 شماره
صفحات -
تاریخ انتشار 2006